Detection of trace elements in children and its clinical value

Abstract

While only in minute quantities in the body, trace elements are crucial co-factors and regulators of normal metabolism. Commonly tested elements include calcium, magnesium, iron, zinc, and copper. Imbalance or deficiencies in trace elements can cause growth retardation, malnutrition, immune malfunction and other abnormalities in children. Because these elements are in trace amounts, sensitivity and reproducibility of detection methods are of paramount importance. Different methods for the same element can yield different reference intervals, which, in order to be applied in the clinic, would have to be independently established by individual laboratories. Clearly defined indications and good quality control to ensure accuracy and sensitivity are necessary for the measurement of trace elements to provide objective reference for clinical diagnosis.(Chin J Lab Med, 2016, 39: 240-242) Key words: Trace elments; Reference values; Child