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Abstract
Sera obtained from rats with intact thyroids after a calcium stress inhibit bone resorption in tissue culture. The inhibitory activity in serum was equivalent to that of 1-2 MRC mU of thyrocalcitonin (TCT)/ml. It appeared with hypercalcemia and disappeared when serum calcium concentration fell. The active material could be extracted from the serum with oxycellulose and further isolated by column chromatography. Its behavior when subjected to extraction and Sephadex chromatography was identical with that of TCT extracted from rat thyroid glands. No TCT activity could be detected in the serum of rats not subjected to calcium stress either by direct assay or after oxycellulose extraction. This suggests that the activity is less than .05 MRC mU/ml in normal animals. (Endocrinology 86: 1231, 1970)
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