Abstract
125I-labeled fibrinogen was used to monitor the formation of venous thrombi on the surface of standard Teflon® and experimental acrylic acid-grafted polyethylene catheters in dogs. By using narrow collimation, it was possible to scan both the indwelling catheter and the vein in increments of 1 cm or less. Both 125I-canine fibrinogen and 125I-human fibrinogen were used in these studies, with essentially the same results. The test accurately detected thrombi forming on the catheter, and thrombi weighing as little as 1.8 mg (wet weight) were located without difficulty. We believe that the test is useful for screening blood contact materials, and is well suited for use in human subjects.
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