Abstract
For over the last twenty years there has been a multitude of sophisticated three-dimensional radiation delivery procedures developed which requires a corresponding verification of the impact on patients. This article reviews the state of the art in the development of chemical detectors used to characterize the three-dimensional shape of therapeutic radiation. These detectors are composed of polyurethane, radical initiator and a leuco dye, which is radiolytically oxidized to a dye absorbing at 630 nm.
Highlights
Radiotherapy treatment is a complex 3D process, which is the principle treatment modality for most cancers [1]
There have been reports of high failure rates for complex radiation treatments [3,4]. These concerns and others have led many to recognize an urgent need to strengthen the foundations of quality assurance (QA) in radiation therapy [3,4]
The ideal dosimeter would be firm in structure and tissue equivalent [14]. This review describes such a 3D dosimeter, which we have been studying since 2004, composed primarily of the polymer polyurethane containing a radiochromic leuco dye and a radical initiator [15]
Summary
Radiotherapy treatment is a complex 3D process, which is the principle treatment modality for most cancers [1]. Scheme 1: Ionizing radiation reactions in the Fricke dosimeter. The leuco dyes by themselves are not oxidized at clinical radiation doses.
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