Abstract
This study aimed to compare the apparent diffusion coefficient (ADC) values of malignant breast lesions with different histopathological types on diffusion-weighted imaging (DWI) and the cellular region/stroma (CR/S) ratio and histopathological results. Breast diffusion-weighted magnetic resonance findings of 59 patients were retrospectively analyzed for malignant breast lesions. The CR/S ratio was calculated using breast wide-excisional biopsy or mastectomy specimens. Receiver operating characteristic analysis was performed for malignant lesions and subtypes. An ADC threshold of 1.260 × 10 –3 mm 2 /s was set to detect invasive ductal carcinoma with 80.8% sensitivity and 81.4% specificity. An ADC threshold of 1.391 × 10 –3 mm 2 /s was set to detect invasive lobular carcinoma lesions with 88.2% sensitivity and 79.5% specificity. The ADC value for lesions with low CR/S ratio (n = 21) was 1.135 ± 0.429 × 10 –3 mm 2 /s and it was 1.155 ± 0.429 × 10 –3 mm 2 /s in the high CR/S ratio group (n = 18). ADC value calculation does not seem to be used as an alternative for histopathological detection, which is the gold standard for the differentiation of subtypes of malignant breast cancer. In addition, since there is a positive correlation between CR/S ratio and ADC values, it may be a strong marker to evaluate the stromal component of lesions.
Highlights
Magnetic resonance imaging (MRI) is a radiological method that has started to be used increasing frequently in the evaluation of breast lesions [1,2]
apparent diffusion coefficient (ADC) value calculation does not seem to be used as an alternative for histopathological detection, which is the gold standard for the differentiation of subtypes of malignant breast cancer
Since there is a positive correlation between cellular region/stroma (CR/S) ratio and ADC values, it may be a strong marker to evaluate the stromal component of lesions
Summary
Magnetic resonance imaging (MRI) is a radiological method that has started to be used increasing frequently in the evaluation of breast lesions [1,2]. Rapid sequences and functional examinations can be performed. Diffusion weighted imaging (DWI) is one of these rapid MRI sequences [3]. Diffusion occurs as a result of the movements driven by the intrinsic molecular kinetic energy. The magnitude of the gradient applied in diffusion measurement is represented with the “b” value, a parameter that indicates the strength and timing of the gradient in s/mm. The apparent diffusion coefficient (ADC) within tissue can only be measured when there are a minimum of two different “b” values. The most commonly used sequence in diffusion MRI is the single-
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