Detection of species – and tissue - unrestricted conformation – dependent tumor associated antigen(s) in immune complexes from plasma of tumor affected cattle and buffaloes

Abstract

Rabbit hyperimmune serum against intact whole immune complexes from a mammary tumor affected dog gave positive reactivity in dot ELISA with plasma from cattle and buffaloes affected with various tumors compared to sera against the antigen – rich and the antibody – rich fractions of dissociated circulating immune complexes (CICs). These results suggest a possibility of existence of species – and tissue unrestricted tumor associated antigens (TAAs) as conformation dependent epitope(s) in CICs in bovine tumors.