Abstract
Objective To investigate the role of serum osteopontin in the occurrence of pemphigus vulgaris (PV) . Methods Enzyme-linked immunosorbent assay was conducted to determine serum levels of osteopontin in 31 patients with PV and 35 healthy human controls. Statistical analysis was carried out by t test and Spearman rank correlation analysis with the SPSS 17.0 software and Excel. Results Serum levels of osteopontin were significantly higher in patients with PV than in healthy controls (P < 0.01) , in patients with mucocutaneous involvement than in those with only cutaneous involvement (P < 0.05) , and in patients with complicated infections than in those without (P < 0.01) . There was a positive correlation between serum levels of osteopontin and anti-Dsg3 antibody in patients with PV (rs = 0.489, P < 0.01) . Conclusions Serum levels of osteopontin are increased in patients with PV, especially in those with mucocutaneous involvement, and positively correlated with PV-related antibody titers. Key words: Pemphigus; Osteopontin; Enzyme-linked immunosorbent assay
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