Abstract
Detection of Rabies Virus and its Pathological Changes in Brain of Buffaloes in Egypt
Highlights
Rabies virus (RABV) belongs to genus Lyssavirus, family Rhabdovirus, causes an acute, fatal, neurological disease of the central nervous system, spreads among domestic dogs and wild carnivorous animals by biting and infects all warm-blooded animals including humans
The world health organization (WHO) currently reports, the fluorescent antibody test (FAT) to be as the best test for detection of rabies viral antigen using a conjugated monoclonal antibody against the rabies nucleocapsid protein (Hayman et al, 2011), which appears as fluorescence
Once inside the CNS, rapid dissemination of the virus occurs with serious pathological changes in the brain as neuronal necrosis, neuronophagia, satellitosis, and perivascular cuffing and rapid progressive encephalitis ensues (Fishbein and Bernard, 1995)
Summary
Rabies virus (RABV) belongs to genus Lyssavirus, family Rhabdovirus, causes an acute, fatal, neurological disease of the central nervous system, spreads among domestic dogs and wild carnivorous animals by biting and infects all warm-blooded animals including humans. RABV replicates in muscle cells prior to the invasion of the peripheral nervous system and central nervous system (Murphy and Bauer, 1974), it propagates along nerve tissue from the wound to the brain causing serious neurological manifestations in the central nervous system. Buffalo is an important species reared in the Egyptian farms and villages; they usually are exposed to biting by rabid dogs and foxes causing fatal nervous manifestations with eventual death. We concerned to detect the viral antigen by fluorescence techniques, evaluate the characteristic histopathological and ultrastructure alterations of the infected brains and investigate the effect of rabies on the endothelial lining of brain blood barriers of infected buffaloes
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