Abstract
Under short-acting anesthesia, the right hemithorax of 11 dogs was irradiated with 800 and 1000 to 1200 rnds (/sup 60/Co), and blood samples were taken sequentially for 36 hr. Three other dogs were anesthetized but not irradiated, for controls. The activities of plasma lactic dehydrogenase (LDH) snd its isoenzymes were assayed before and after irradiation. The relation between the earliest morphological changes after irradiation and activity changes in LDH/sub 3/, which is specific to lung and associated with acute pulmonary injury were studied. There was no significant change in total LDH or LDH/sub 3/ activity in either the controls or the group receiving 800 rads. In dogs receiving 1000 to 1200 rads LDH activity was twice that of controls at 2 hr after irradiation (P < 0.05), and returned to control by 4 hr. LDH/sub 3/ was elevated 15 min after irradiation and rose to three times control by 2 hr (P < 0.05). Ultrastructural charges in alveolar and capillary epithelium were found only in this group. Plasma LDH/sub 3/ activity may be a useful index to even minimal acute pulmonary irradiation injury. (auth)
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