Abstract
Detecting the signal backscattered by nanoparticles immersed in highly scattering media such as biological tissue remains a challenge. In this article we report on the use of Full Field OCT (FF-OCT) to slice in depth in phantoms and in tissues in order a) to selectively observe the particles through the backscattered light at suitable wavelengths, and b) to detect the effects of the time-dependent response to full field optical heating through the strong absorption cross-section of these plasmonic nanoparticles. The analysis of the thermal wave behavior leads to the localization of the heat sources even when FF-OCT signals cannot reach the heated area.
Highlights
Plasmonic probes such as gold nanoparticles have advantage of being biocompatible, nontoxic and having/showing a good chemical stability [1]
In this article we report on the use of Full Field optical coherence tomography (OCT) (FF-OCT) to slice in depth in phantoms and in tissues in order a) to selectively observe the particles through the backscattered light at suitable wavelengths, and b) to detect the effects of the time-dependent response to full field optical heating through the strong absorption cross-section of these plasmonic nanoparticles
The analysis of the thermal wave behavior leads to the localization of the heat sources even when FF-OCT signals cannot reach the heated area
Summary
Plasmonic probes such as gold nanoparticles have advantage of being biocompatible, nontoxic and having/showing a good chemical stability [1]. The spectral region between 650 and 900 nm, called therapeutic window, shows low absorption of hemoglobin (900 nm). Based on their unique optical and plasmonic properties, gold nanoshells were used as contrast agent for optical imaging such as photoacoustic imaging (PAI), photoacoustic tomography (PAT) [7,8], optical coherence tomography (OCT) [9,10,11,12,13] and photothermal OCT [14,15,16,17,18,19]
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