Detection of patients with delayed afterdepolarization using cardiac magnetic field mapping at rest

Abstract

Event Abstract Back to Event Detection of patients with delayed afterdepolarization using cardiac magnetic field mapping at rest Taysia Sosnytska1*, Leonyd Stadnyuk1 and Volodymyr Sosnytskyy2 1 P.L. Shupik Medical Academy for Postgraduate Education of UH Ministry, Ukraine 2 Glushkov Institute of Cybernetics, MCG Laboratory, Ukraine Objective. Human ventricular cells studies have shown that the Na+/Ca2+ exchange current (INa/Ca) contribute to the transient inward current (Iti). Iti is responsible for the proarrhythmic delayed afterdepolarizations (DADs). Although DADs are generally accepted to be Ca2+-dependent, the relationship between sarcopasmic reticulum Ca2+ release and DAD amplitude has not been measured, partly because the underlying Ca2+ -activated currents are hard to control. The overall objective of the present study was to demonstrate the efficacy of magnetocardiography (MCG) in the diagnosis of the Ca2+ overload in some area of the heart in patients presenting with DADs. Methods. Standard clinical examination (e.g. Tissue Doppler echocardiograms (TDE), 12-channel ECG, 24-h Holter monitoring) and MCG were performed in 24 patients (age 25±1.9) affected by DADs and 22 (age 27±1.9) healthy controls. MCG was recorded by means of 4x3–channel MCG system (Kiev Medical Group Ltd, Ukraine) in an unshielded setting. Current density vector (CDV) maps were plotted by the magnetic moments method of the “inverse problem solution”. MCG based indices, namely direction of the largest CDV, its deviation, shift and current density total sum during electric diastole interval were performed using an automated MCG analysis program. Results. Two MCG based parameters showed a significant difference between DADs patients and the control groups. We also found that verapamil, the prototype calcium-channel blocker, effects these parameters in patients. Conclusion. We conclude MCG is a promising procedure for a non-invasive testing and localization of an area of the heart which provides a substrate that favors electrical abnormalities and lately arrhythmias. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: MCG: Instrumentation, Modeling, Basic and Clinical Studies Citation: Sosnytska T, Stadnyuk L and Sosnytskyy V (2010). Detection of patients with delayed afterdepolarization using cardiac magnetic field mapping at rest. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00331 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 06 Apr 2010; Published Online: 06 Apr 2010. * Correspondence: Taysia Sosnytska, P.L. Shupik Medical Academy for Postgraduate Education of UH Ministry, Kiev, Ukraine, t_sosnytskaya@mail.ru Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Taysia Sosnytska Leonyd Stadnyuk Volodymyr Sosnytskyy Google Taysia Sosnytska Leonyd Stadnyuk Volodymyr Sosnytskyy Google Scholar Taysia Sosnytska Leonyd Stadnyuk Volodymyr Sosnytskyy PubMed Taysia Sosnytska Leonyd Stadnyuk Volodymyr Sosnytskyy Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.