Abstract
Object: To isolate and identify the microorganisms from the burn patients admitted to the National Institute of Burn and Plastic Surgery Unit in Tertiary Medical College Hospital, Bangladesh. A total number of fifty wound surface swab samples of first and second-degree burn patients were collected and the microbial analysis as well as the study of antibacterial susceptibility was conducted. The study showed the bacterial isolates were found. 45 (90%) of wound swab were positive among 50 and only 5 samples (10%) were negative in bacterial growth, which presented invasive burn wound infection from both sex age groups marked 12 - 60 years. The total viable count TVC-11651 CFU/plate was found and the highest amount in the second-degree burn patients. The results showed that Pseudomonas aeruginosa was common in all positive samples 6636 CFU/plate (57%) followed by Staphylococcus aureus 4070 CFU/plate (35%), Klebsiella spp. 450 CFU/plate (5%), Proteus spp. 243 CFU/plate (2%), and E. coli 162 CFU/plate (1%). Most of the pathogens were found to be drug-resistant while several isolates were noted to be multi-drug resistant. The growth of multidrug-resistant organisms should be considered as a serious risk factor in a burn unit. Aggressive infection control measures should be applied to limit the emergence and spread of multidrug-resistant pathogens.
Highlights
Burn injury is one of the most common and devastating forms of trauma and a major public health concern all around the world
The results showed that Pseudomonas aeruginosa was common in all positive samples 6636 CFU/plate (57%) followed by Staphylococcus aureus 4070 CFU/plate (35%), Klebsiella spp
An important clinical consideration has to be taken on the fact that since E. coli and Klebsiella pneumonia are well known to be the extended spectrum β-lactamase producers; these isolates found in our study may be further subjected for study [23] [24] and the prevalence of bacteria in 50 burn wound swabs was shown in the bacterial isolates were found in 45 (90%) wound swab samples, and only 5 samples (10%) were negative in bacterial growth
Summary
Burn injury is one of the most common and devastating forms of trauma and a major public health concern all around the world. Nosocomial infections (NI) are common in burn patients due to the typical features of the disease: loss of the first line of defense against microbial invasion; the presence of devitalized, a vascularized tissue that provides a favorable environment for microbial growth; alterations in the specific and nonspecific components of the immune system; gastrointestinal translocation; and extended hospitalization and multiple invasive diagnostic and therapeutic procedures [13] [14]. The situation is alarming in developing as well as developed countries due to indiscriminate use of antibiotics [15], pharmaceutical industries have produced a large number of newer antibiotics in the last three decades The reason behind this is that microorganisms are becoming resistant to both older and newer antibiotics [16]. There are a lot of antimicrobial drugs of which some are discovered or established [20] [21]
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