Detection of oxidative stress induced by ciprofloxacin in imatuer rat

Abstract

Fluoroquinolones are a group of antibiotics broadly used because of their wide spectrum activity against both Gram-negative and Gram positive bacteria. It is well tolerated in patients but their uses have been associated with numerous adverse effects, including adverse central nervous system (CNS) effects and juvenile joint toxicity due to oxidative stress. This study designed to detect the oxidative stress caused by administration of ciprofloxacin alone and in concert with glutathione. Ciprofloxacin (400 mg/kg body weight) administered to rats alone or with glutathione (100 mg/kg) body weight for7 days injection via intra peritoneal route to detect effects on glutathione peroxidase and glutathione reductase as oxidative stress enzymes markers. The data obtained demonstrated presence of the two enzymes which supplies further evidence that fluoroquinolones at therapeutic doses promote oxidative stress and the crucial role of glutathione in ptotection against ciprofloxacin side effects on bone.