Abstract
Objective:To investigate the incidence of oral infection with Helicobacter pylori (H. pylori) and identify related epidemiological factors among freshmen of four colleges in Yancheng.Methods:The data, scored positive or negative, were collected on 160 individuals who had been diagnosed by H. pylori Saliva Test Cassette (HPS) during October 2013 to October 2014. H. pylori Saliva Test Cassette (HPS) is to use colloidal gold technique to specifically identify urease in saliva. A standard questionnaire, with variables including sex, educational degree of parents etc., was used in the subjects. Statistical data of diagnostic test were analyzed by SPSS17.0 software.Results:Out of 160, 82 subjects were detected positive and 78 were negative. In univariate analysis, dental plaque, family history of stomach diseases, habit of washing hands before meals and habit of brushing teeth twice daily were associated negatively with H. pylori infection. Multivariate logistic regression analysis showed that dental plaque and family history of stomach diseases were the risk factors which may be associated with H. pylori infection.Conclusions:Dental plaque and family history of gastric diseases were risk factors of oral H. pylori infection. It is vital for the prevention of H. pylori infection to focus on health education and oral hygiene, and avoid transmission by oral-oral route as well.
Highlights
It has attracted extensive attention that Helicobacter pylori infection correlates closely to chronic gastritis, peptic ulcer and gastric cancer.[1,2] H. pylori were considered as group 1 carcinogen by the International Agency for Research on1
At level of α=0.05, risk factors associated with oral H. pylori infection were preliminarily screened: dental plaque (OR=2.245, 95% CI: 1.129-4.463, p=0.020), Table-I: Univariate analysis of risk factors for oral H.pylori infection
In previous publications regarding the detection of H. pylori infection in dental plaque and saliva, clinical patients were recruited as study population[15,16] and there were no references pertaining to the oral infection status in the general population
Summary
It has attracted extensive attention that Helicobacter pylori infection correlates closely to chronic gastritis, peptic ulcer and gastric cancer.[1,2] H. pylori were considered as group 1 carcinogen by the International Agency for Research on. Diagnostic tests of H. pylori infection include invasive and noninvasive methods. Noninvasive tests such as immunoassay for serological antibodies against H. pylori, 13C Urea Breath Test and 14C-Urea Breath Test (UBT), are more acceptable. Detection of oral Helicobacter Pylori infection testing can readily be manipulated, as many studies have reported.[9,10] it was seldom reported regarding saliva H. pylori antigen testing.[11] H. pylori Saliva Test Cassette (HPS) is to use monoclonal antibody to identify urease in saliva after H. pylori infection. HPS is a new noninvasive method, which is especially applicable to detect oral H. pylori infection. We expect to improve the knowledge of H. pylori infection among youngsters, help those with high risk factors attach importance to periodic checks, and provide basis for prevention programs as well
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