Detection of non-ST-elevation myocardial infarction using magnetocardiogram: New information from spatiotemporal electrical activation map

Abstract

Background and aim. Non-ST-segment elevation myocardial infarction (NSTEMI) cannot be easily detected in the emergency room. We evaluate a method to detect NSTEMI using 64-channel magnetocardiography (MCG).Methods. MCG recordings were made in 20 NSTEMI patients (aged 59.7±12.4 years), 15 young (aged 26.8±3.4 years), and 13 age-matched control subjects (aged 57.3±3.6). We evaluated three approaches to analysis, including 1) determination when individual subjects’ MCG results fell outside normal ranges for ten MCG parameters, 2) the magnetic field map at the T-wave peak (T-MFM), and 3) a pair of spatiotemporal activation graphs (STAGs) showing two projections of electrical excitation during repolarization.Results. Significant differences were found between normal controls and patients for all MCG parameters. None of the healthy controls had more than four MCG abnormal parameters, whereas 19 NSTEMI patients (95%) were abnormal in more than four parameters. STAGs and T-MFM also showed clear differences between healthy controls and NSTEMI patients.Conclusions. These results suggest that the MCG is sensitive to changes in the cardiac electrical pathway after myocardial infarction as described by these graphs and parameters, and therefore MCG may be a useful tool to detect severe ischemic patients.