Abstract
Chitosan (CS) provides more electrochemical active sites due to its large number of hydroxyl and amino groups. MXene can provide support sites for CS to construct novel MXene@CS composites. This work uses Ti3C2Tx@CS as a bioactive membrane. Gold nanoparticles and biotin-labeled horseradish peroxidase were made as amplification elements. The complexes formed by immunoreactivity with CYFRA21–1, streptavidin-labeled carcinoembryonic antibodies are immobilized on the Ti3C2Tx@CS. The assembled immunoelectrochemical sensor was used for the highly sensitive detection of CYFRA21–1. The results showed that the novel immunosensor exhibited a good linear range (2–20 ng/mL, R2 = 0.9941) with a detection limit of 1.7 ng/mL.
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