Abstract
With the aging global population and the rising burden of Alzheimer disease and related dementias (ADRDs), there is a growing focus on identifying mild cognitive impairment (MCI) to enable timely interventions that could potentially slow down the onset of clinical dementia. The production of speech by an individual is a cognitively complex task that engages various cognitive domains. The ease of audio data collection highlights the potential cost-effectiveness and noninvasive nature of using human speech as a tool for cognitive assessment. This study aimed to construct a machine learning pipeline that incorporates speaker diarization, feature extraction, feature selection, and classification to identify a set of acoustic features derived from voice recordings that exhibit strong MCI detection capability. The study included 100 MCI cases and 100 cognitively normal controls matched for age, sex, and education from the Framingham Heart Study. Participants' spoken responses on neuropsychological tests were recorded, and the recorded audio was processed to identify segments of each participant's voice from recordings that included voices of both testers and participants. A comprehensive set of 6385 acoustic features was then extracted from these voice segments using OpenSMILE and Praat software. Subsequently, a random forest model was constructed to classify cognitive status using the features that exhibited significant differences between the MCI and cognitively normal groups. The MCI detection performance of various audio lengths was further examined. An optimal subset of 29 features was identified that resulted in an area under the receiver operating characteristic curve of 0.87, with a 95% CI of 0.81-0.94. The most important acoustic feature for MCI classification was the number of filled pauses (importance score=0.09, P=3.10E-08). There was no substantial difference in the performance of the model trained on the acoustic features derived from different lengths of voice recordings. This study showcases the potential of monitoring changes to nonsemantic and acoustic features of speech as a way of early ADRD detection and motivates future opportunities for using human speech as a measure of brain health.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Similar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.