Abstract
In this study we report the detection of the recently described mcr-4 gene in two human isolates of Salmonella enterica serovar Typhimurium. The strains were isolated from faecal samples of two Italian patients with gastroenteritis, collected in 2016. The identified mcr-4 genes (variant mcr-4.2) differed from the mcr-4 gene originally described in a Salmonella strain of swine origin from Italy. Salmonella species could represent a hidden reservoir for mcr genes.
Highlights
In this study we report the detection of the recently described mcr-4 gene in two human isolates of Salmonella enterica serovar Typhimurium
In the context of an analysis into the epidemiology of mobile colistin determinants, we investigated a collection of 106 human clinical isolates of Enterobacteriaceae
These isolates were obtained between January 2016 and October 2017 in two main hospitals in Emilia Romagna, Italy, namely IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia and Sant’Agostino-Estense Hospital of Baggiovara
Summary
Detection of mcr-4 positive Salmonella enterica serovar Typhimurium in clinical isolates of human origin, Italy, October to November 2016. In this study we report the detection of the recently described mcr-4 gene in two human isolates of Salmonella enterica serovar Typhimurium. In the context of an analysis into the epidemiology of mobile colistin determinants, we investigated a collection of 106 human clinical isolates of Enterobacteriaceae These isolates were obtained between January 2016 and October 2017 in two main hospitals in Emilia Romagna, Italy, namely IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia and Sant’Agostino-Estense Hospital of Baggiovara. Among the 67 Escherichia coli, 27 Klebsiella pneumoniae, six Salmonella species and six other Enterobacteriaceae collected, we detected the mcr-4 gene in two human isolates of S. enterica subsp. The mcr-4 gene was not detected in any other isolate of the above collection; further analyses for other mcr genes are ongoing in these and additional isolates
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