Abstract
Liver is the commonest site of distant metastases in gastrointestinal cancer ( 1 Parker S.L. Tong T. Bolden S. et al. Cancer statistics, 1997. CA Cancer J Clin. 1997; 47: 5-13 Crossref PubMed Scopus (2312) Google Scholar ). Early detection of liver metastases is paramount, especially in colorectal cancer because of improved 2-year survival rates following hepatic metastatectomy as compared to non-surgical therapy ( 2 Hughes K. Scheele J. Sugarbaker P.H. Surgery for colorectal cancer metastatic to the liver optimizing the results of treatment. Surg Clin North Am. 1989; 69: 339-359 PubMed Google Scholar , 3 Fusai G. Davidson B.R. Management of colorectal liver metastases. Colorectal Dis. 2003; 5: 2-23 Crossref PubMed Scopus (95) Google Scholar ). Imaging influences the treatment strategy, for example; resectable lesions may benefit from curative resection ( 4 Kato T. Yasui K. Hirai T. et al. Therapeutic results for hepatic metastasis of colorectal cancer with special reference to effectiveness of hepatectomy analysis of prognostic factors for 763 cases recorded at 18 institutions. Dis Colon Rectum. 2003; 46 (Oct): S22-S31 PubMed Google Scholar ) and those not suitable for surgery may be considered for other therapies like hepatic artery chemoembolization, radio frequency ablation and systemic chemotherapy. Therefore, accurate staging of liver metastases is a surgical prerequisite. Contrast enhanced MRI is now routinely used for staging liver cancer. MRI has been shown to be equally sensitive and specific to CT arterial portography in focal liver lesion detection ( 5 Semelka R.C. Schlund J.F. Molina P.L. et al. Malignant liver lesions comparison of spiral CT arterial portography and MR imaging for diagnostic accuracy, cost and effect on patient management. J Magn Reson Imaging. 1996; 6: 39-43 Crossref PubMed Scopus (59) Google Scholar ). FDG-PET imaging is emerging as an important method for staging gastrointestinal malignancies ( 6 Fong Y. Cohen A.M. Fortner J.G. et al. Liver resection for colorectal metastases. J Clin Oncol. 1997; 15: 938-946 Crossref PubMed Scopus (1075) Google Scholar ). We retrospectively reviewed imaging, pathology and surgical data in patients with gastrointestinal cancer who underwent both MnDPDP enhanced liver MRI and whole body FDG-PET for detection of metastatic disease in order to assess the relative performance of each modality in liver lesion detection.
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