Abstract
BackgroundS100A14 is a novel significant individual from S100 proteins family. Its significance is because of its part in tumorigenesis and metastasis process. Elevated level of S100A14 was associated with poor tumor differentiation. A relatively high dose of S100A14 was capable to induce cell injuries. It was discovered that S100A14 is seen at the extracellular medium. S100A14 induces the activation of apoptotic mediators and cell apoptosis. The aim of this study is to assess the clinical response of S100A14 in the detection the stages of liver fibrosis in patients of chronic HCV. ELISA was used to detect the levels of serum S100A14 in both different stages of fibrosis of the liver and control groups, and then, they were noticed together with the results of fibroscan. Other noninvasive markers of fibrosis were calculated such as APRI, AAR, and FIB-4 score.ResultsProtein expression level of S100A14 was positive correlated significantly with stages of fibrosis.ConclusionMeasurement of serum level of S100A14 is a useful non-invasive marker for detection of the stages of liver fibrosis in patients of chronic HCV. Combinations of measuring S100A14 level to FIB-4 or S100A14 to APRI give a sensitive tool for diagnosing significant fibrosis.
Highlights
S100A14 is a novel significant individual from S100 proteins family
Liver diseases with many types lead to liver fibrosis by means of signaling networks integrated that control the sedimentation of extracellular matrix
There is a high significant increase in fibrosis group compared to the control group which can be noticed at Table 2 and Fig. 1 upon the comparison between the fibrosis group and control group as regards S100A14
Summary
S100A14 is a novel significant individual from S100 proteins family. Its significance is because of its part in tumorigenesis and metastasis process. The activation of hepatic stellate cell is the inevitable essential event in fibrosis, and they become the primary source of extracellular matrix (ECM) in the liver after injury [1]. Liver diseases with many types lead to liver fibrosis by means of signaling networks integrated that control the sedimentation of extracellular matrix. This cascade of responses drives the activation of hepatic stellate cells (HSCs) into a myofibroblastlike phenotype which is contractile, proliferative, and fibrogenic. We were aiming in this study to discover the clinical efficiency of the level of S100A14 as a marker for detection of the liver fibrosis stages in Egyptian patients
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