Abstract
Chicken kidney cells, derived from the eggs of white leghorn chickens that had serological evidence of prior exposure to both adenovirus and the adeno-associated virus (AAV), produced AAV antigenic proteins upon challenge with purified adenovirus. Antigen was detected by indirect immunofluorescence using monoclonal antibody to AAV. The number of fluorescent cells were few and did not increase during the course of adenovirus infection. Similar results were obtained using cells prepared from specific-pathogen-free chicks with no previous exposure to adenovirus or AAV. It is postulated that the avian AAV can exist as a latent infection in the germ line of chickens.
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