Detection of Labyrinthine Fistulas in Human Temporal Bone by Virtual Endoscopy and Density Threshold Variation on Computed Tomographic Scan

Abstract

To assess the sensitivity of the routine computed tomographic (CT) scan of the temporal bone coupled to a virtual endoscopy, with density threshold variation, in detecting small fistulas in human temporal bone specimens. Single-blind, before-after trial. This study was carried out in a research laboratory in collaboration with a radiology department. Five human adult temporal bone specimens were included. The fistulas were created with calibrated burrs (0.3, 0.5, and 0.8 mm) in the 3 semicircular canals and in the promontory of 3 temporal bones. Two other temporal bones served as controls. All bones underwent CT scan (1-mm section thickness) before and after dissection. Three-dimensional images were obtained from CT scan native axial views at different density reconstruction thresholds. The virtual endoscope was placed in the middle ear cavity looking to the inner ear wall. The threshold at which a bony defect appeared on virtual endoscopic images (opening threshold in Hounsfield units [H]) was noted for each location. Opening thresholds before and after dissection. On standard axial views, fistulas smaller than 0.5 mm were not visualized. By virtual endoscopy, all fistulas could be visualized. The opening threshold decreased after fistula creation in the semicircular canals (1244 +/- 50.5 H [n = 36] vs 778 +/- 52.4 H [n = 34]; P<.001; 1-way analysis of variance and Dunnett multiple comparisons posttest) and in the promontory (1541 +/- 37.8 H [n = 12] vs 1334 +/- 35.1 H [n = 8]; P<.001). The opening thresholds in the control specimens remained unchanged after dissection. Virtual endoscopy with variation of reconstruction threshold allows the detection of small labyrinthine fistulas with diameters of 0.3 mm or smaller.