Abstract
Introduction Molecular MRI has emerged as a promising, non-invasive modality to accurately detect high-risk atherosclerotic plaques. Due to the inherently low sensitivity of MRI, contrast agents targeted at an abundant and robust component of the lesion are required. Fibrin represents a clinically relevant target and imaging of aortic, coronary, carotid and cardiac thrombi have been demonstrated both in animal models and men. It has been recognised as an important component of atherosclerotic plaques and is present throughout plaque development.
Highlights
Molecular MRI has emerged as a promising, non-invasive modality to accurately detect high-risk atherosclerotic plaques
This study aimed to investigate the feasibility of intraplaque fibrin detection throughout plaque development with EP-2104R, a fibrin targeted contrast agent, in an in vivo mouse model of progressive atherosclerosis
MRI with EP-2104R significantly enhanced the plaques (Figure 1) in the brachiocephalic arteries of 4, 8 and 12 week high fat diet (HFD) mice compared to their respective non-contrast enhanced images (P < 0.05), and wild-type control mice (P < 0.05)
Summary
Molecular MRI has emerged as a promising, non-invasive modality to accurately detect high-risk atherosclerotic plaques. Due to the inherently low sensitivity of MRI, contrast agents targeted at an abundant and robust component of the lesion are required. Fibrin represents a clinically relevant target and imaging of aortic, coronary, carotid and cardiac thrombi have been demonstrated both in animal models and men. It has been recognised as an important component of atherosclerotic plaques and is present throughout plaque development. This study aimed to investigate the feasibility of intraplaque fibrin detection throughout plaque development with EP-2104R, a fibrin targeted contrast agent, in an in vivo mouse model of progressive atherosclerosis
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