Detection of immune response cells, blood indicators, and enzymatic antioxidants in individuals with cutaneous leishmaniasis

Abstract

One of the most significant zoonotic pathogens in humans, leishmaniasis, can result in serious, potentially fatal infections. This study aimed to assess the degree of the immune response in children with cutaneous leishmaniasis. The analysis of some blood parameters in the affected children revealed significant differences (P<0.05) in the hemoglobin rate, which was lower in the patient populations compared with the control group. The findings revealed a statistical difference in the values of the heterogeneous tiers of INF-Y, IL6, IL10, SOD, GPX, and CAT between the sick and healthy children (P 0.05). However, this rise will not only cause the parasite to die but also cause oxidative damage to the affected child's cells and tissues and may reach a level that is impossible to control, indicating the incidence of oxidative DNA damage and the beginning of an infection. Keywords: Cytokines, enzymatic antioxidants, cutaneous leishmaniasis