Abstract
30Jun 2016 DETECTION OF IL-28 rs 12979860 GENE POLYMORPHISM BY REAL TIME PCR IN HEPATOCELLULAR CARCINOMA PATIENTS. Amal A. Mohamed , Ingy Badawy , Waleed A. Elagawy and AbeerA.Abdelmonem. Department of Biochemistry, National Hepatology and Tropical Medicine Institute, Cairo, Egypt. Faculty of Biotechnology, Misr university for Science and technology, Cairo, Egypt. Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute Cairo, Egypt. Microbiology and Immunology, Beni-Suef Faculty of Medicine.
Highlights
Background:- Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. It commonly develops on cirrhotic livers, and surveillance programs have been suggested to identify early HCC, at a stage when it remains suitable for surgical therapy and has a better clinical outcome
Conclusion:-This study demonstrated the beneficial role of single nucleotide polymorphisms (SNPs) rs12979860 allele of IL28B gene for predicting the Hepatocellular carcinoma related to hepatitis C virus (HCV) patients
The rate of HCC is increasing in Egypt where the major risk factors are chronic infections with hepatitis B and C viruses (HBV & HCV), other risk factors involves aflatoxin B1 exposure, pesticides, alcohol consumption, and genetic defects (But et al, 2008).In Europe and North America, it commonly develops on cirrhotic livers, and surveillance programs have been suggested to identify early HCC, at a stage when it remains suitable for surgical therapy and has a better clinical outcome
Summary
DETECTION OF IL-28 rs 12979860 GENE POLYMORPHISM BY REAL TIME PCR IN HEPATOCELLULAR CARCINOMA PATIENTS. Mohamed[1], Ingy Badawy[2], Waleed A. 1. Department of Biochemistry, National Hepatology and Tropical Medicine Institute, Cairo, Egypt. 2. Faculty of Biotechnology, Misr university for Science and technology, Cairo, Egypt. 3. Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute Cairo, Egypt. 4. Microbiology and Immunology, Beni-Suef Faculty of Medicine
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