Abstract
Richter’s transformation (RT) represents the development of high grade lymphoma, most commonly diffuse large B-cell lymphoma, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). CLL/SLL may convert also to Hodgkin’s lymphoma, the so-called Hodgkin’s variant of Richter transformation. Histopathological proof is needed to confirm a definitive diagnosis. Patients with RT generally have a poor prognosis, with prompt recognition optimise clinical management. Whole-body PET scan with 18F-FDG can be used for detection of RT of CLL/SLL. We describe the case of 64-year-old woman with CLL/SLL who developed Hodgkin lymphoma detected with PET/CT.
Highlights
Chronic lymphocytic leukemia (CLL), the most common type of adult leukemia, is characterized by a monoclonal proliferation of mature B-cell lymphocytes with distinctive phenotypic features [1]
The histology seen in patients with Richter’s transformation (RT) is the diffuse large B-cell lymphoma (DLBCL), prolymphocytic leukemia as well as Hodgkin lymphoma (HL) and T-cell lymphoma
We report the case of a 64-year-old female with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who developed Hodgkin’s lymphoma detected by PET/CT
Summary
Chronic lymphocytic leukemia (CLL), the most common type of adult leukemia, is characterized by a monoclonal proliferation of mature B-cell lymphocytes with distinctive phenotypic features [1]. Development of high-grade non-Hodgkin’s lymphoma (NHL) in patients with CLL or SLL is termed as Richter’s transformation (RT) [3]. We report the case of a 64-year-old female with CLL/SLL who developed Hodgkin’s lymphoma detected by PET/CT.
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