Detection of growth-restricted fetuses during pregnancy is associated with fewer intrauterine deaths but increased adverse childhood outcomes: an observational study.

Abstract

Exploring associations between antenatal detection of fetal growth restriction (FGR) and adverse outcome. Retrospective, observational, register-based study. Zealand, Denmark. Children born from 1 September 2012 to 31 August 2015. Diagnoses from birth until 1 January 2018 were retrieved from The National Patient Registry. Detection was defined as estimated fetal weight less than the 2.3rd centile. Cox regression was used to associate detection status with the hazard rate of adverse outcome, adjusted for fetal weight deviation, maternal age, ethnicity, body mass index and smoking. Adverse neonatal outcome, adverse neuropsychiatric outcome, respiratory disorders, endocrine disorders, gastrointestinal/urogenital disorders. A total of 2425 FGR children were included. An association was found for gastrointestinal/urogenital disorders (hazard ratio [HR] 1.68, 95% CI 1.26-2.23, P<0.001) and respiratory disorders (HR 1.22, 95% CI 1.02-1.46, P=0.03) in detected versus undetected infants. For adverse neuropsychiatric outcome, HR was 1.32 (95% CI 1.00-1.75, P=0.05). There was no evidence of an association between detection and adverse neonatal outcome (HR 1.00, 95% CI 0.62-1.61, P=0.99) and endocrine disorders (HR 1.39, 95% CI 0.88-2.19, P=0.16). Detected infants were smaller (median -28% versus -25%, P<0.0001), more often born preterm (odds ratio [OR] 4.15, 3.12-5.52, P<0.0001) and more often born after induction or caesarean section (OR 5.19, 95% CI 4.13-6.51, P<0.0001). Stillbirth risk was increased in undetected FGR fetuses (OR 2.63, 95% CI 1.37-5.04, P=0.004). We found an association between detection of FGR and risk of adverse childhood conditions, possibly caused by prematurity. Iatrogenic prematurity may be inevitable in stillbirth prevention, but is accompanied by a risk of long-term childhood conditions. Antenatal detection of growth-restricted fetuses is associated with adverse childhood outcomes but fewer intrauterine deaths.