Abstract
Pure shear-wave resonances were excited and detected in 18- and 30-µm-thick electrodeless AT-cut quartz plates in liquids using line antennas contactlessly, achieving high-frequency quartz-crystal microbalances (QCMs). Their fundamental resonance frequencies (85 and 54 MHz) were monitored to study interactions in real time between human glypican-3 and an anti-glypican-3 antibody: glypican-3 is a prospective protein marker for hepatocellular carcinoma. Their affinity was determined by the Langmuir kinetics. This study demonstrates the high ability of the wireless-electrodeless QCM for detection of the protein markers and development of drugs for disorders.
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