Abstract
The effects of Low-Dose Radiation (LDR) on human health are still debated, despite LDR being ubiquitous in our environment, such as via radioactive substance leakage following an accident at a nuclear facility, as well as medical exposure for diagnosis and radiotherapy.
Highlights
The effects of Low-Dose Radiation (LDR) on human health are still debated, despite LDR being ubiquitous in our environment, such as via radioactive substance leakage following an accident at a nuclear facility, as well as medical exposure for diagnosis and radiotherapy
We reported in a previous paper that the dose conferring HRS was 75 mGy with γ-rays from a 60Co source in human normal fibroblast cells [2]
Research concerning the effects of LDR and High-Dose Radiation (HDR) on the genome has been increasing and the research can be applied for the diagnosis and cure of cancers [3,4,5,6,7,8]
Summary
The effects of Low-Dose Radiation (LDR) on human health are still debated, despite LDR being ubiquitous in our environment, such as via radioactive substance leakage following an accident at a nuclear facility, as well as medical exposure for diagnosis and radiotherapy. We reported previously that the radiation dose conferring HRS was 75 mGy with γ-rays from a 60Co source in human normal fibroblast cells. To examine whether LDR causes any alterations in genomic DNA, especially in cancer-related genes, high-throughput generation sequencing (NGS) was adopted.
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