Abstract
Detection of Gamma Interferon and Some Pro-Inflammatory Cytokines in SPF Chicks Experimentally Infected with Chicken Anemia Virus
Highlights
Chicken infectious anemia is an important worldwide disease in the poultry industry (Balamurugan and Kataria, 2006)
Hosts typically respond to viral invasion by mounting complex, multifaceted, defensive immune responses that include substantial induction of type I IFNs (IFN-α and IFN-β), initial production of pro-inflammatory cytokines (IL-1β, IL-6 and CXCLi2 (IL-8 like chemokine), to drive Th1 responses with subsequent induction of the relevant Th1 cytokines, later production of anti-inflammatory cytokines to switch off the inflammatory responses after viral clearance to limit immunopathology and activation of apoptotic pathways
This study demonstrated the viral load in body organs and viral specific antibody titres of the specific pathogen free (SPF) chicks experimentally intramuscularly infected with chicken anemia virus (CAV) and its contact group
Summary
Chicken infectious anemia is an important worldwide disease in the poultry industry (Balamurugan and Kataria, 2006). Hosts typically respond to viral invasion by mounting complex, multifaceted, defensive immune responses that include substantial induction of type I IFNs (IFN-α and IFN-β), initial production of pro-inflammatory cytokines (IL-1β, IL-6 and CXCLi2 (IL-8 like chemokine), to drive Th1 responses with subsequent induction of the relevant Th1 cytokines, later production of anti-inflammatory cytokines to switch off the inflammatory responses after viral clearance to limit immunopathology and activation of apoptotic pathways These are all accompanied by notable changes in gene expression. This study demonstrated the viral load in body organs and viral specific antibody titres of the SPF chicks experimentally intramuscularly infected with CAV and its contact group. Spleen, bone marrow and thyroid were collected for application of Quantitative real time polymerase chain reaction (qRTPCR) to determine the viral copy number in the tissues of CAV-infected, contact and negative control chicks. After 18 h, the diameter of the cleared zones was measured and the lysozyme concentration was estimated from standard logarithmic curve
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