Abstract
The confirmation of asthma diagnosis and the evaluation of asthma severity pose time-consuming and expensive inhalation challenges. Their objective is to provoke and register by means of spirometry or airway resistance measurements the naturally occurring asthmatic episodes, and rely on the intelligent and conscientious cooperation on the part of the tested subjects. An alternative method for detection of airway obstruction was developed using measurement of the changes in chest basic electrical impedance Zo during methacholine inhalation challenges. A large surface tetrapolar electrode arrangement was applied to reduce motion artifacts to an acceptable level. A coherent association between spirometric and Zo changes was obtained in all tested subjects. As Zo measurements are not dependent on the cooperation of those tested, this approach has the potential to be used for fluctuating airway obstruction monitoring.
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