Detection of early protein-calorie malnutrition (pre-kwashiorkor) in population groups.

Abstract

1. The heights and weights and the serum total protein concentration and ratio nonessential to essential amino acids (NEA:EA ratio) were determined in twenty-six Indian children, aged from 1·5 to 5 years, suffering from early protein-calorie malnutrition (pre-kwashiorkor children).2. The heights and weights of the majority of the children approximated to 75–85% of the values for normal Indian children. The serum NEA:EA ratio of the children varied from 2·5 to 4·0. There was no correlation between this ratio and weight deficit. In healthy children of the same socio-economic group, the serum NEA:EA ratio varied from 1·5 to 2·1 with a mean of 1·7. The results show that the NEA:EA ratio may be useful as an index for the detection of pre-kwashiorkor conditions.3. There was a significant (P< 0·05) negative correlation (r = −0·45) between serum albumin and NEA:EA ratio of the children. All the children showed consistently a significant increase in serum γ-globulin.