Detection of dopamine by a minimized electrochemical sensor using a graphene oxide molecularly imprinted polymer modified micropipette tip shaped graphite electrode

Abstract

A simple and efficient electrochemical sensor based on a homemade reshaped micropipette tip carbon paste electrode is reported. Molecularly imprinted polymer membranes of graphene oxide and polypyrrole are synthesized and modified on the surface of micropipette tip carbon paste electrode. The merit of the method is evaluated under optimized conditions via differential pulse voltammetrics. The prepared sensor exhibits remarkable sensitivity toward dopamine with a linear range of 6.4 × 10−8–2 × 10−4 M, with a limit of detection as low as 1 × 10−8 M. The proposed method is applied for the determination of dopamine in urine samples by the standard addition route. A range of 1 × 10−7–1 × 10−4 M is obtained from these samples. The relative recoveries are in the range of 95.2%–104%. The proposed method has acceptable performance for the determination of dopamine in real samples with excellent sensitivity and selectivity.