Abstract
Objective: Increased incidence of germ cell aneuploidy has been noted in men with idiopathic infertility. By using 3-color (chromosome 18, X, Y) fluorescence in situ hybridization (FISH), individual sex-chromosome aneuploidy rate in mitotic and meiotic germ cells could be calculated. However, meiosis is a process of 2 consecutive cell divisions, which leads to the formation of secondary spermatocytes (after first division) and spermatids (after second division). It is not possible to analyze the non-disjunction rate of the individual meiotic division based only on the FISH signals. The secondary spermatocytes and the spermatids are both haploid cells and both have haploid FISH signals.
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