Detection of Clostridium difficile toxins A/B in the stool specimens from patients and medical staff of the children's antituberculosis department

O H Ivanko,Ya S Skrypnykova,M V Patsera

doi:10.14739/2310-1210.2018.5.141724

O H Ivanko, Ya S Skrypnykova + Show 1 more

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https://doi.org/10.14739/2310-1210.2018.5.141724

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Abstract

Detection of Clostridium difficile toxins A/B in the stool specimens from patients and medical staff of the children's antituberculosis department

Highlights

Over the past decade, a significant increase in mortality from an infection caused by Clostridium difficile (C. difficile infection or CDI) has been observed in the North American continent and Europe [1,2]
The role of C. difficile asymptomatic carriage as an infectious reservoir for the CDI development in patients within the hospital is increasingly recognized. This fact involves the transmission of strains from asymptomatic carriers who have begun antibacterial therapy, as well as from patients who have been in hospital for a long time or who have received pathogenic strains from medical personnel [11,12]
The objective of our research was to determine the detection frequency of C. difficile toxins A/B in the stool specimens from children receiving long-term antibiotic treatment and simultaneously in medical personnel treating these children in a separate anti-tuberculosis hospital

Summary

Introduction

A significant increase in mortality from an infection caused by Clostridium difficile (C. difficile infection or CDI) has been observed in the North American continent and Europe [1,2]. Patients with manifest forms of CDI and asymptomatic carriers could spread the spores that lead to both direct (a person-to-person contact) and indirect C. difficile transmission [9]. The role of C. difficile asymptomatic carriage as an infectious reservoir for the CDI development in patients within the hospital is increasingly recognized. This fact involves the transmission of strains from asymptomatic carriers who have begun antibacterial therapy, as well as from patients who have been in hospital for a long time or who have received pathogenic strains from medical personnel [11,12]. The importance of C. difficile asymptomatic carriage in intestinal clostridiosis occurrence requires the revision of measures in order to protect and prevent the development of CDI among patients and hospital staff [13,14]

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