Detection of CD146 level in patients with hypertensive disorders in pregnancy and its association with retinal vascular lesions

Abstract

Objective To explore the association of severity of disease and retinal vascular lesion staging with the level of serum C D 146 from different types of hypertensive disorders in pregnancy (HDIP) patients and normal pregnancy women.Methods One hundred and thirteen cases of women giving birth from January 2010 to January 2012 in Department of Gynecology and Obstetrics,Beijing Tongren Hospital,Capital Medical University were recruited,including 73 HDIP patients and 40 normal pregnant women.HDIP patients were divided into 3 groups according to the severity of disease:gestational hypertension group (n=22),mild preeclampsia group (n=23) and severe preeclampsia group (n=28).Normal pregnant women were used as normal pregnancy group (n=40).Prenatal and postnatal serum CD146 levels in 4 groups were detected by ELISA,and the correlation between CD146 levels and HDIP severity or retinal vascular lesion staging were analyzed.Results There were significant differences in serum CD146 levels of 4 groups prenatal and postnatal (all P＜0.05),and the CD146 levels increased with the severity of disease.CD 146 expression in preeclampsia of mild,severe group was significantly higher than that in normal pregnancy group and gestational hypertension group (all P＜0.05).The C D 146 levels in postnatal of 4 groups decreased as compared to those in prenatal (all P＜0.05).All the subjects were divided into 4 groups according to different stages of retinopathy,and there were significant differences in serum CD146 levels of 4 groups prenatal or postnatal (all P＜0.05),and the levels of serum CD146 increased with the severity of retinopathy.There were significant correlations between phases of retinal lesion and the severity of HDIP during prenatal and postnatal stage (prenatal:rx=0.793,P＜0.05; postnatal:rs=0.631,P＜0.05).Conclusion CD146 level may be used as an index reflecting the severity of HDIP and retinopathy. Key words: Hypertension, pregnancy-induced; Antigens, CD146; Pregnancy complications