Detection of cancer affected cell using Sagnac interferometer based photonic crystal fiber refractive index sensor

Abstract

The light interaction with the cell of any part or organ of the body gives useful information regarding the changes in optical properties for different cells. A photonic crystal fiber, selectively filled by the sample cell is proposed to detect the cancer cell based on the refractive index (RI). Upon considering the change of optical properties of the proposed fiber due to different RI of normal and cancer cell, sensitivities are attained of 11,428.57, 17,142.85, 31,428.57, and 34,285.71 nm/RIU for Jurkat, PC12, MCF-7, and MDA-MB-231 cell from the transmission spectrum obtained by the Sagnac interferometer phenomena.