Abstract
THE presence of C-reactive protein in human serum is a highly sensitive index of inflammation or of tissue destruction1. It appears in the blood serum as early as 14 hr. after the injury occurs. Present knowledge points towards its being a β-globulin2, but its origin and function are yet unknown. The methods available for the detection of C-reactive protein are based on precipitation3,4, complement-fixation5, haemagglutination6 and gel-diffusion7 techniques, methods which are unsuitable for the precise localization of the substance in cells. For this purpose the fluorescent antibody technique seemed to be promising. Results of staining blood smears from people who are positive and negative for C-reactive protein with the fluorescent antibody techniques are described here.
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