Abstract
Objective To discuss the changes of blood lipids, homocysteine (Hcy) and endothelin (ET) levels in patients with hypothyroidism and subclinical hypothyroidism, and to explore their clinical significance. Methods The authors choose 255 cases of hypothyroidism, 274 cases of subclinical hypothyroidism and 130 cases of the control group to test serum TC, TG, HDL, LDL, LPa, Hcy and ET. The correlation were analyzed. Results The level of TC, TG, LDL of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group, HDL is lower than the control group. The level of TC, TG, LDL of hyperthyroidism group is higher than subclinical hyperthyroidism group, HDL is lower than subclinical hyperthyroidism group. The level of Hcy of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group. The level of Hcy of hyperthyroidism group is higher than subclinical hyperthyroidism group. The level of ET of hyperthyroidism group is lower than the control group and subclinical hyperthyroidism group. Conclusions All of blood lipids, Hcy and ET participate in the development process of hypothyroidism and subclinical hypothyroidism which is of great value in predicting the transition of thyroid dysfunction and the occurrence of adverse consequences.
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