Abstract
The sensor response of 5 MHz gold electrode coated quartz crystal microbalances (QCMs) towards various environments for human endometrial stromal and mesenchymal stem cells growth is reported. The deposition of endometrial stromal cells onto sensor surface causes mass loading dependent resonance frequency downshift of 1.5 kHz and a corresponding increase in the dynamic resistance of 403 Ω. Furthermore, the QCMs demonstrate ability to detect negligible changes in the viscosity/density product of different biological environments. In addition, the sensors show reproducible sensor characteristics with maximum deviations from measurement to measurement within 50 Hz. The observed deviations are lower compared to the sensor signal, thereby confirming that the QCMs could be used as in situ detectors of various biological compounds or interactions, closely related to the in vitro fertilization analysis. These experiments open a possibility for integration of wide range in vitro investigations on lab-on-a-chip devices.
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