Detection of biochemical markers levels among COVID-19 patients, recovered and vaccinated groups of people

Abstract

The new virus first appeared in the Chinese city of Wuhan in 2019 and spread around the world, like the outbreak of the Coronavirus (COVID-19), causing severe acute respiratory syndrome in humans, which can be fatal to individuals at risk. The primary purposes of this study are to assess the diagnostic power of the following biochemical (D dimer, CRP, LDH and serum ferritin) markers in identifying the diagnosis and severity of COVID-19 and to find out the differences in these hematological and biochemical markers among COVID 19 patients and recovered. The study included (50) patients diagnosed with COVID-19 (25 males and 25 females) who visited Al-Hussein Teaching Hospital in ThiQar province, (50) Patients recovering from COVID-19 infection, (50) People who have received COVID-19 vaccines and (50: 25 people were vaccinated with Sinopharm and 25 people were vaccinated with Pfizer) healthy subjects as a control group. The study population age ranged from (20-70 years) old. Specialist physicians diagnosed all patients with COVID-19 in this study, which was confirmed by clinical and laboratory tests, especially polymerase chain reaction PCR. The results of the current study have shown that there is a significant difference(PValue < 0.05) between the study groups according to the age group in each of the levels (D dimer, LDH, serum ferritin). The current study also revealed a significant difference between the study groups according to gender in each of (D. dimer, LDH), and there is no significant difference in each of (CRP, serum ferritin). A significant difference is expected where the difference between the two averages is between the patients' COVID-19 group and the control group, the recovered group, or the vaccinated group(LSD of D. dimer >95.10, LSD of CRP>11.86, S. ferritin >120.61, LSD of LDH>75.45) and no significant between control and recovered. An increase in the levels of the following vital signs for patients with COVID-19: D dimer, CRP, LDH, and serum ferritin. In the recovered groups, the levels were normal. Keywords: biochemical markers, COVID19, recovered and vaccinated group of people