Abstract
Interactions of bioactive compounds such as bitter substances, odorous compounds, anaesthetics, surfactants, and antibiotics, with lipid multibilayers were studied using a quartz-crystal microbalance (QCM) deposited with lipid multilayers. The amount of adsorption (partition coefficient) or the penetration behaviour of these compounds with lipid matrices could be obtained quantitatively at the nanogram level from the decrease in frequency of the lipid multibilayer-deposited QCM in aqueous solutions. The partition coefficients obtained for the bioactive compounds into the lipid matrix gave a good linear correlation with their properties such as their bitter taste, intensity of smell, potency as anaesthetics or the toxicity of surfactants, and intensity of antibiotics. The lipid-coated QCM will become a new tool to determine the affinity of hydrophobic bioactive compounds for lipid matrices in aqueous solutions.
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