Abstract
Laser Doppler flowmetry (LDF) examination was conducted in 11 FAP patients, 3 asymptomatic carriers of FAP and 29 normal controls. The vasoconstrictive responses induced by deep inspiration in the 11 FAP patients were markedly depressed, compared with those in healthy volunteers. In the 7 patients advanced to the stages 2 (moderate) to 4 (terminal), the responses were not elicited at all. To our interest, the vasoconstrictive responses following deep inspiration were also depressed in two of the 3 asymptomatic carriers of FAP, who had normal sensory nerve conduction velocity. Some patients with other diseases, such as Shy-Drager disease and pandysautonomia, also failed to exhibit the decrease of blood flow for various stimulations. Thus, these data suggest that the autonomic nervous system, especially the sympathetic vasomotor nerve regulating peripheral circulation, might be affected prior to the somatic polyneuropathy in FAP patients.
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