Abstract
A new rat model of recurrent pulmonary aspergillosis using cyclophosphamide (CPM) for re-institution of immunosuppression was established. The recurrence induced by CPM was rapid and pulmonary lesions were uniform in all animals. It is therefore considered to be a good model for evaluation of the mechanisms of recurrence and methods of early diagnosis by antigen detection in sera and urine. Galactomannan antigen of aspergilli in sera was examined by PASTOREX Aspergillus, and a very low positive rate was observed instead of the of severe pulmonary infection confirmed by histopathological study. However, antigen in urine detected by immunoblotting showed a relatively high positive rate from the early stage of the recurrence. Based on these findings, it can be concluded that the recognition of antigenuria is useful for early diagnosis of Aspergillus infection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
