Detection of Anti-viral Drug Riamilovir and Herbicides in Aqueous Media by Using Pyrene-based Fluorescent Chemosensors

D S Kopchuk,L K Sadieva,O S Taniya,I S Kovalev,O N Chupakhin,E N Ulomsky,V L Rusinov,G V Zyryanov

doi:10.15826/chimtech.2021.8.2.08

D S Kopchuk, L K Sadieva + Show 6 more

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https://doi.org/10.15826/chimtech.2021.8.2.08

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Abstract

Two ethyleneglycol esters of 1-pyrene carboxylic acid were studied as chemosensors for the fluorescence “turn-off” detection of two nitro-containing analytes, such as antiviral drug Riamilovir (Triazavirin ®) and herbicidal agent dinitro-ortho-cresol (DNOC). In both cases the dramatic fluorescence quenching was observed with quenching constants as high as 3·104 M-1 and limits of detection (LOD) as low as 100 ppb.

Highlights

One of the scourges of modern civilization is the coronavirus (SARS-CoV-2) pandemic that broke out in the end of the 2019
Despite the fact that the antiviral drug Riamilovir (Triazavirin ®) is not a specific drug against SARSCoV-2, it has successfully shown itself among other drugs in reducing the incidence of respiratory, cardiac, hepatic, renal and other complications, associated with coronavirus infection (COVID-19) [1,2]
It is still widely used in Russia and other countries. In this manuscript we would like to report our study of sensory abilities of the pyrene-based polyethyleneglycol water-soluble fluorescent “turn-off” chemosensors toward nitro-containing drug Riamilovir and herbicide DNOC

Summary

Introduction

One of the scourges of modern civilization is the coronavirus (SARS-CoV-2) pandemic that broke out in the end of the 2019. Fluorescence-based methods are the robust and convenient methods of measuring drug concentration in the biological (water-based) liquids and target organs [3,4]. DNOC has been identified in at least 56 of the 1854 hazardous waste sites that have been proposed for inclusion on the EPA National Priorities List (NPL) [6]. It is still widely used in Russia and other countries. In this manuscript we would like to report our study of sensory abilities of the pyrene-based polyethyleneglycol water-soluble fluorescent “turn-off” chemosensors toward nitro-containing drug Riamilovir and herbicide DNOC

Experimental

Results and Discussion

Conclusions