Abstract
IN:Background and Aim: Infection of Toxoplasma gondii is a worldwide distribution. Toxoplasmosis in patients who are immunocompromised by virtue of underlying leukemia disease has received relatively little attention. This study was aimed to evaluate IgG and IgM antibodies of T. gondii and to minimize the role of T. gondii and opportunistic infection complication at the early stage of infection in leukemia patients.Materials and Methods:The purpose of this assay was to measure anti-T. gondii IgG and IgM antibodies by enzyme-linked immunosorbent assay (ELISA) technique in leukemia patients.Results:IgG antibodies against T. gondii were detected by ELISA in 96 (56.4%) leukemia patients and 72 (42.4%) control group. IgM antibodies were found in 10 patients (5.9%) with leukemia and 3 (1.8%) in the corresponding.Conclusion:Our finding indicated that leukemia patients under immunosuppressive condition should not be neglected. Toxoplasmosis in leukemia patients as a main risk factor is considered, meanwhile in some patients, due to possibility of the presence of secondary infection that leads to severe toxoplasmosis.
Highlights
Toxoplasma gondii is a zoonotic coccidian obligate, intracellular protozoan parasite, which humans and other warm-blooded animals are its hosts [1]
IgG antibodies against T. gondii were detected by enzymelinked immunosorbent assay (ELISA) in 96 (56.4%) leukemia patients and 72 (42.4%) control group
Toxoplasmosis in leukemia patients as a main risk factor is considered, in some patients, due to possibility of the presence of secondary infection that leads to severe toxoplasmosis
Summary
Toxoplasma gondii is a zoonotic coccidian obligate, intracellular protozoan parasite, which humans and other warm-blooded animals are its hosts [1]. The infection has a worldwide distribution, and the incidence of the disease varies around the world [2]. The parasite’s bradyzoites can persist inside human cells for long time periods, but recent infection can be reactivated, such as in the case of AIDS which T. gondii reactivation causes severe encephalitis [5]. In this regard, the prevalence of T. gondii can induced encephalitis to reach up to 40% in patients with AIDS in which 10-30% die from this parasitic disease [6]. Infection of Toxoplasma gondii is a worldwide distribution. This study was aimed to evaluate IgG and IgM antibodies of T. gondii and to minimize the role of T. gondii and opportunistic infection complication at the early stage of infection in leukemia patients
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