Detection of Anti-CMV IgM and Anti-Toxoplasma gondii IgG in Pregnant Women with History of Abortion

Abstract

Background and objectives: Several infection are associated with abortion among them toxoplasmosis and cytomegalovirus infection. Toxoplasma gondii causes congenital toxoplasmosis along with HCMV a highly teratogenic virus that interfere emberyogenesis. Both infections are almost asymptomatic thus, diagnosis depends primarily on serological tests namely ELISA to detect antibodies in serum of pregnant women. Methods: A semi-quantitative Elisa technique is applied for detection of anti-toxoplasma IgG and anti-CMV IgM in sera of 348 pregnant women tested in Rezan Private Lab who have previously experienced abortion. Results: The seropositivity rates are 29.05% for Toxoplasma-IgG and 45.25% for CMV-IgM. The increasing age is associated with increasing times of abortion (p ≤ 0.0001). Cases with co-infection are more likely to have multiple abortions. The number of abortions is statistically not highly associated with socioeconomic status of pregnant women (p ≥ 0. 1364). Conclusion: Through this study a plain connection can be figured out between chance of multiple times of abortion and infections caused by CMV and Toxoplasma gondii. Similarly, this association is verified more with increasing age while the socioeconomic status of cases is not indicative for the possibility of multiple miscarriages. All these results are rationally expected and in agreement with most other studies.