Abstract
ObjectiveTo evaluate the imaging findings of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and computed tomography (CT) in patients with additional primary tumors, correlating the results with those of the method used in order to elucidate the diagnosis and of the pathology reports.Materials and MethodsWe retrospectively analyzed the medical records, pathology reports and images of 11 patients who underwent CT, 18F-FDG PET/CT, or both. We included patients with at least two tumors, with confirmed distinct histopathological profiles, at different sites. Patients in whom there was no diagnostic confirmation were excluded, as were those in whom the additional lesion was suspected of being a metastasis of the first.ResultsNew primary malignancies were identified in 11 patients, one new tumor being found in 10 and two new tumors being found in 1. The confirmed sites of the additional malignancies were the lung, kidney, prostate, jejunum, and breast. Single or multiple percutaneous biopsies were performed in 10 patients, and 1 patient underwent a surgical procedure for diagnostic and therapeutic purposes. The tumors were metachronous in 6 cases and synchronous in 5.ConclusionCT and 18F-FDG PET-CT combined with multiple percutaneous biopsy could facilitate the diagnosis of additional lesions, thus optimizing the treatment and follow-up of the affected patients.
Highlights
Multiple primary tumors can be defined as more than one, histologically different, synchronous or metachronous lesion in the same individual[1]
Objective: To evaluate the imaging findings of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FFDG PET/CT) and computed tomography (CT) in patients with additional primary tumors, correlating the results with those of the method used in order to elucidate the diagnosis and of the pathology reports
CT and 18F-FDG PET-CT combined with multiple percutaneous biopsy could facilitate the diagnosis of additional lesions, optimizing the treatment and follow-up of the affected patients
Summary
Multiple primary tumors can be defined as more than one, histologically different, synchronous or metachronous lesion in the same individual[1]. Uncommon, their incidence and prevalence have been progressively increasing, due in large part to the increase in life expectancy of the population and to advances in diagnostic techniques[2]. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has emerged as a promising imaging modality in the evaluation of malignant tumors[3]. Studies indicate that the introduction of 8F-FDG PET/CT images to evaluate malignant tumors results in better detection of multiple primary tumors[4,5]
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