Abstract
PURPOSE: In human plasma the normal M-type A1PI occurs in several isoforms that are molecules with different numbers of sialic acids (isoforms M1, M2, M4, M6) or missing 5 N-terminal amino acids (M7, M8) In addition alpha1-proteinase inhibitor (A1PI) concentrates lack the C terminal amino acid lysine. The latter was shown to derive from the action of basic carboxypeptidases during the ethanol fractionation process. Having previously shown that carboxypeptidase M can cleave off the C-terminal lysine and lung tissue contains high levels of this enzyme, we investigated human BAL solutions for the occurrence of the C-terminal truncated A1PI isoform.
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