Detection methods of minimal residual disease in childhood malignant solid tumors

Abstract

Despite that survival rates have been improved in childhood malignant solid tumors, progression during treatment or relapse after complete remission remain a major cause hindering patients from getting long-time survival.Minimal residual disease(MRD)is closely related to relapse of solid tumors.This review discusses the advance and value of various methods used in MRD detection, aiming to establish a stable and reliable method for MRD detection. Key words: Childhood malignant tumor; Minimal residual disease; Methodology